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Question
Biology
Posted 10 months ago
why the protein can be found in the endoplasmic reticulum lumen and the extracellular matrix.
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Answer from Sia
Posted 10 months ago
Answer
Proteins can be found in the endoplasmic reticulum lumen and the extracellular matrix because they are synthesized in the ER and some are secreted or incorporated into the ECM for structural support, signaling, and other functions.
Solution
a
Protein synthesis and processing: Proteins are synthesized by ribosomes. Ribosomes attached to the rough endoplasmic reticulum (ER) synthesize proteins that are destined for the ER lumen, where they undergo folding and post-translational modifications
b
Secretory pathway: After proper folding and modification in the ER, proteins are transported to the Golgi apparatus for further processing. From there, they can be directed to various destinations, including the extracellular matrix (ECM), where they perform various functions
c
Structural and functional roles in ECM: In the ECM, proteins like collagen, elastin, and fibronectin provide structural support, facilitate cell adhesion, and play roles in signaling pathways
Key Concept
Protein localization in the ER and ECM
Explanation
Proteins are localized to the ER lumen for synthesis and processing, and some are transported to the ECM to fulfill structural and functional roles.

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