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Question
Biology
Posted 10 months ago
how is mobility not restricted to double strand dna breaks
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Answer from Sia
Posted 10 months ago
Answer
Mobility in the genome is not solely a consequence of double-strand DNA breaks (DSBs).
Solution
a
Single-strand DNA breaks (SSBs) and base modifications: These can lead to repair processes that involve local unwinding and potential movement of DNA segments
b
Transposable elements: These are DNA sequences that can change their position within the genome, independently of DSBs, through a "cut and paste" or "copy and paste" mechanism
c
DNA replication: During replication, the DNA polymerase can slip or disengage, leading to loop structures that can be resolved through recombination, resulting in segmental duplications or deletions without the need for DSBs
Key Concept
DNA mobility encompasses a variety of mechanisms beyond double-strand breaks, including single-strand breaks, transposable elements, and replication-based processes.
Explanation
DNA can move or be rearranged through several mechanisms that do not necessarily involve the breaking of both strands, such as repair of single-strand breaks, activity of transposable elements, and errors during DNA replication.

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