Why is lactate converted to pyruvate in the liver?

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∻Answer∻ ⚹ Lactate is converted to pyruvate in the liver to allow for gluconeogenesis and to regenerate NAD+ for glycolysis in muscles. ⚹ ∻Solution∻ ‖ a ⋮ Lactate as a substrate for gluconeogenesis: Lactate produced by anaerobic glycolysis in muscles is transported to the liver, where it is converted back to pyruvate. ‖ ‖ b ⋮ Regeneration of NAD+: The conversion of lactate to pyruvate is catalyzed by the enzyme lactate dehydrogenase (LDH), which also regenerates NAD+ from NADH. This is crucial for maintaining the NAD+/NADH ratio required for continuous glycolysis in muscles. ‖ ‖ c ⋮ Cori Cycle: The process of lactate conversion to pyruvate in the liver and its subsequent use in gluconeogenesis, followed by the transport of glucose back to the muscles, is known as the Cori Cycle. ‖ ∻Key Concept∻ ⚹ Lactate to Pyruvate Conversion in the Liver ⚹ ∻Explanation∻ ⚹ This conversion is essential for gluconeogenesis and maintaining the NAD+/NADH balance, which is vital for continuous energy production during anaerobic conditions. ⚹◊How does the conversion of lactate to pyruvate in the liver help regulate the body's pH balance?⍭ Generate me a similar question◊

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