Which of the following mutations would be likely to produce S. pombe cells that are enlongated and which require a long time to complete mitosis?

Group of answer choices

A mutation that abolishes $\mathrm{Cdc} 25$ activity.

A mutation that increases activity of $\mathrm{Cdc} 25$.

A mutation that increases activity of CAK.

A mutation in CDK that prevents it from being phosphorylated by Wee1.

A mutation that abolishes Wee1 activity.

Question

Which of the following mutations would be likely to produce S. pombe cells that are enlongated and which require a long time to complete mitosis?

Group of answer choices

A mutation that abolishes $\mathrm{Cdc} 25$ activity.

A mutation that increases activity of $\mathrm{Cdc} 25$.

A mutation that increases activity of CAK.

A mutation in CDK that prevents it from being phosphorylated by Wee1.

A mutation that abolishes Wee1 activity.

Accepted Answer

***A*** ∻Key Concept∻ ⚹Cell cycle regulation by Cdc25⚹ ∻Explanation∻ ⚹Cdc25 is a phosphatase that activates the cyclin-dependent kinase (CDK) by removing inhibitory phosphates. A mutation that abolishes Cdc25 activity would prevent CDK activation, delaying the cell cycle at the G2/M checkpoint and resulting in elongated S. pombe cells due to prolonged mitosis.⚹◊How does the regulation of $Cdc25$ and Wee1 activity impact cell morphology and mitosis progression in S. pombe?⍭ Generate me a similar question◊

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