Which 2 types of mutations cause the most harm? Why are they so harmful? Are they near the beginning of the mRNA or near the end?

Question

Which 2 ﻿types of mutations cause the most harm? Why are they so harmful? Are they near the beginning of the mRNA or near the end?

Accepted Answer

∻Answer∻ ⚹ The two types of mutations that cause the most harm are frameshift mutations and nonsense mutations. ⚹ ∻Solution∻ ‖ a ⋮ Frameshift mutations: These occur when nucleotides are inserted or deleted from the DNA sequence, causing a shift in the reading frame of the mRNA. This shift alters the entire downstream amino acid sequence, often resulting in a nonfunctional protein. ‖‖ b ⋮ Nonsense mutations: These occur when a point mutation changes a codon that codes for an amino acid into a stop codon. This results in premature termination of protein synthesis, leading to a truncated and usually nonfunctional protein. ‖ ∻Key Concept∻ ⚹ Frameshift and nonsense mutations are highly disruptive to protein function. ⚹ ∻Explanation∻ ⚹ Frameshift mutations alter the reading frame, affecting all downstream amino acids, while nonsense mutations introduce premature stop codons, truncating the protein. Both types of mutations typically result in nonfunctional proteins, which can severely impact cellular functions. ⚹◊What are the potential consequences of frameshift mutations in DNA sequences and how do they affect protein synthesis⍭ Generate me a similar question◊

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