What would happen to the chromosomes in a eukaryotic cell that underwent several rounds of mitosis without telomerase?

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Accepted Answer

∻Answer∻ ⚹ The chromosomes would shorten with each round of mitosis, potentially leading to loss of genetic information and cell malfunction or death. ⚹ ∻Solution∻ ‖ a ⋮ Telomere shortening: Without telomerase, the telomeres at the ends of chromosomes shorten with each round of mitosis. ‖ ‖ b ⋮ Genetic information loss: As telomeres shorten, they may eventually reach a critical length where important genetic information is lost during cell division. ‖ ‖ c ⋮ Cell senescence or apoptosis: Cells may enter a state of senescence (aging) or undergo programmed cell death (apoptosis) when critical telomere shortening occurs. ‖ ∻Key Concept∻ ⚹ Telomere shortening in the absence of telomerase ⚹ ∻Explanation∻ ⚹ Telomeres protect chromosome ends, and without telomerase to maintain them, cells can age or die after multiple mitotic divisions. ⚹◊How would the shortened telomeres affect the cell's ability to divide through mitosis?⍭ Generate me a similar question◊

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