Sia
Question
Biology
Posted 10 months ago
The amount of fumarate used to form ATP is approx. equal to that required for the urea cycle and gluconeogenesis, meaning that
Sign in to unlock the answer
Answer from Sia
Posted 10 months ago
Answer
The amount of fumarate produced in the urea cycle is used to generate ATP in the mitochondria, which can then be used for gluconeogenesis.
Solution
a
Fumarate production in the urea cycle: Fumarate is generated in the urea cycle when argininosuccinate is cleaved into arginine and fumarate
b
Conversion of fumarate to malate: Fumarate is transported into the mitochondria where it is hydrated to form malate by the enzyme fumarase
c
Malate to oxaloacetate conversion: Malate is then oxidized to oxaloacetate by malate dehydrogenase, producing NADH
d
ATP generation: The NADH produced can enter the electron transport chain to ultimately generate ATP
e
Gluconeogenesis utilization: The oxaloacetate can be used as a substrate for gluconeogenesis to form glucose
Key Concept
The urea cycle and gluconeogenesis are interconnected metabolic pathways, with fumarate linking the two.
Explanation
Fumarate produced in the urea cycle can be used to generate ATP, which is necessary for gluconeogenesis, thus connecting the energy requirements of both processes.
Not the question you are looking for? Ask here!
Enter question by text
Enter question by image
Unlock Smarter Learning with AskSia Super!
Join Super, our all-in-one AI solution that can greatly improve your learning efficiency.
30% higher accuracy than GPT-4o
Entire learning journey support
The most student-friendly features
Study Other Question