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Biology
Posted 10 months ago
Phosphofructokinase is inhibited by acid. Which is the best metabolic reason for this?
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Answer from Sia
Posted 10 months ago
Answer
Phosphofructokinase is inhibited by acid as a regulatory mechanism to prevent excessive glycolysis and subsequent lactate accumulation under low pH conditions.
Solution
a
Feedback inhibition : Phosphofructokinase (PFK) is subject to feedback inhibition by hydrogen ions (H⁺), which accumulate when muscle cells undergo anaerobic respiration and produce lactic acid
b
Protection of cellular pH : By inhibiting PFK, the cell prevents further acid production from glycolysis, thus protecting the cell from detrimental low pH levels that can denature proteins and interfere with other metabolic processes
c
Energy conservation : Inhibition of PFK under acidic conditions prevents the unnecessary expenditure of ATP in glycolysis, conserving energy for when conditions are more favorable for ATP production
Key Concept
Metabolic regulation of PFK by pH
Explanation
The inhibition of phosphofructokinase by acid is a metabolic control mechanism that helps maintain cellular homeostasis by preventing excessive acidification and conserving energy.
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