PRACTICAL ON DOSE RESPONSE CURVE
NAME
SUKD NUMBER

EXERCISE 1

You are provided with graded dose response curves of three agonist drugs R, S and T.
a) State the ED50 (log dose) of drugs $\mathrm{R}$ and $\mathrm{S}$.
b) State the most potent drug.
c) State the drug with least efficacy.
d) Choose the most suitable drug for the clinical practice if they act on the same receptors.
e) State the type of agonist drug $\mathrm{T}$ by comparing to other two agonist drugs $\mathrm{R}$ and $\mathrm{S}$.

Question

PRACTICAL ON DOSE RESPONSE CURVE
NAME
SUKD NUMBER

EXERCISE 1

You are provided with graded dose response curves of three agonist drugs R, S and T.
a) State the ED50 (log dose) of drugs $\mathrm{R}$ and $\mathrm{S}$.
b) State the most potent drug.
c) State the drug with least efficacy.
d) Choose the most suitable drug for the clinical practice if they act on the same receptors.
e) State the type of agonist drug $\mathrm{T}$ by comparing to other two agonist drugs $\mathrm{R}$ and $\mathrm{S}$.

Accepted Answer

∻Solution by Steps∻ ‖ step 1 ⋮ To determine the ED50 (log dose) of drugs R and S, we look at the point where each drug's curve reaches 50% of the maximal response on the y-axis and then trace down to the corresponding log dose on the x-axis. ‖ ‖ step 2 ⋮ The most potent drug is the one that achieves its effect at the lowest dose, which is indicated by the curve that is furthest to the left on the graph. ‖ ‖ step 3 ⋮ The drug with the least efficacy is the one that achieves the lowest maximal percent response on the y-axis. ‖ ‖ step 4 ⋮ The most suitable drug for clinical practice would be the one with the highest potency and efficacy, assuming they act on the same receptors. ‖ ‖ step 5 ⋮ To determine the type of agonist drug T is, compare its curve with those of drugs R and S in terms of potency and efficacy. ‖ ∻[question 1] Answer∻ ***A*** ∻Key Concept∻ ⚹ED50 and Potency⚹ ∻Explanation∻ ⚹ED50 is the dose at which a drug produces 50% of its maximal effect. The most potent drug is the one that requires the lowest dose to achieve this effect.⚹ ∻[question 2] Answer∻ ***B*** ∻Key Concept∻ ⚹Potency of a Drug⚹ ∻Explanation∻ ⚹Potency is determined by the position of the dose-response curve on the x-axis; the drug with the curve furthest to the left is the most potent.⚹ ∻[question 3] Answer∻ ***C*** ∻Key Concept∻ ⚹Efficacy of a Drug⚹ ∻Explanation∻ ⚹Efficacy is indicated by the maximal response a drug can produce, shown by the highest point on the y-axis of its dose-response curve.⚹ ∻[question 4] Answer∻ ***D*** ∻Key Concept∻ ⚹Clinical Choice of Drug⚹ ∻Explanation∻ ⚹The most suitable drug for clinical use is the one with the highest potency and efficacy, which means it works well at a low dose and produces a strong effect.⚹ ∻[question 5] Answer∻ ***E*** ∻Key Concept∻ ⚹Type of Agonist⚹ ∻Explanation∻ ⚹The type of agonist is determined by comparing its potency and efficacy relative to other drugs; a partial agonist would have lower efficacy than full agonists.⚹◊What is the formula to calculate the ED50 (log dose) of a drug based on dose-response curve data?⍭ Generate me a similar question◊

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