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Question
Biology
Posted 10 months ago
How is ATP produced from substrate-level phosphorylation? Compare this process with oxidative phosphorylation.
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Answer from Sia
Posted 10 months ago
Answer
ATP is produced from substrate-level phosphorylation by the direct transfer of a phosphate group from a phosphorylated substrate to ADP, resulting in ATP. This process differs from oxidative phosphorylation, which involves the transfer of electrons through a series of membrane proteins to generate a proton gradient that drives ATP synthesis.
Solution
a
Substrate-level phosphorylation: This occurs when a phosphate group is directly transferred from a phosphorylated intermediate to ADP, forming ATP. Examples include reactions in glycolysis and the Krebs cycle
b
Oxidative phosphorylation: This involves the electron transport chain and chemiosmosis. Electrons are transferred through a series of proteins in the inner mitochondrial membrane, pumping protons and creating a gradient. ATP synthase uses this gradient to produce ATP from ADP and inorganic phosphate (Pi)
Key Concept
Substrate-level vs. oxidative phosphorylation
Explanation
Substrate-level phosphorylation directly forms ATP from ADP and a phosphorylated substrate, while oxidative phosphorylation uses an electrochemical gradient to power ATP synthesis.

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