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Question
Biology
Posted 6 months ago
Describe how lagging strand of DNA synthesis occur?
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Answer from Sia
Posted 6 months ago
Answer
DNA synthesis on the lagging strand occurs in a discontinuous manner, producing Okazaki fragments that are later joined together.
Solution
a
Initiation: The lagging strand begins synthesis when primase synthesizes a short RNA primer
b
Elongation: DNA polymerase III extends the RNA primer, adding DNA nucleotides in the 5' to 3' direction, creating Okazaki fragments
c
Primer removal: Once an Okazaki fragment is synthesized, the RNA primer is removed by DNA polymerase I and replaced with DNA nucleotides
d
Ligation: DNA ligase joins the Okazaki fragments by forming phosphodiester bonds between the fragments, resulting in a continuous DNA strand
Key Concept
Lagging strand synthesis is discontinuous due to the antiparallel nature of DNA strands.
Explanation
The lagging strand is synthesized in short segments because DNA polymerase can only add nucleotides in the 5' to 3' direction, and the lagging strand template runs in the 3' to 5' direction.

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