Assume interference between regions $(A-B$ and $B-C)$ is $40 \%$. Then you perform a cross between an F1 individual and an individual with a genotype of abC/abc. Among 1000 progeny, how many will have aabbcc genotype?

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∻Answer∻ ⚹ 250 ⚹ ∻Solution∻ ‖ a ⋮ Calculate the expected frequency of double crossovers without interference: The frequency of double crossovers can be calculated by multiplying the individual frequencies of the two regions. Assuming independent assortment, the frequency of crossovers in region A-B is the same as the frequency in region B-C. ‖ ‖ b ⋮ Apply the interference: Interference reduces the number of expected double crossovers. With 40% interference, we multiply the expected frequency by (1 - interference). ‖ ‖ c ⋮ Determine the number of progeny with the aabbcc genotype: The number of progeny with the aabbcc genotype is the total number of progeny multiplied by the frequency of double crossovers after applying interference. ‖ ∻Key Concept∻ ⚹ Genetic interference ⚹ ∻Explanation∻ ⚹ Interference is a phenomenon where the occurrence of one crossover event reduces the probability of another crossover in an adjacent region. It is quantified as 1 minus the coefficient of coincidence, which is the observed double crossover frequency divided by the expected frequency if crossovers were independent. ⚹◊How does gene interference affect the likelihood of producing progeny with specific genotypes in a cross between F1 individuals?⍭ Generate me a similar question◊

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